Perioperative neurocognitive dysfunction
Conditions
Interventions
Aortic Dissection Subjects:None
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Subjects with no preoperative cognitive dysfunction (MMSE score >= 24) were included. 2.A patient diagnosed with aortic dissection was treated with Sun's procedure (total arch replacement combined with stented elephant trunk implantation), following preoperative lumbar cisternal catheter placement for cerebrospinal fluid drainage. 3.Participants provided informed consent for the collection of biological specimens.
Exclusion criteria
Exclusion criteria: 1.The patient has a history of stroke. 2.The presence of preoperative cognitive impairment (MMSE score < 24). 3.Subjects with a history of severe neuropsychiatric disorders, craniocerebral trauma, drug dependence, alcohol addiction, severe preoperative dementia, or previous cardiac surgery were excluded. 4.The presence of contraindications to spinal (lumbar) puncture. 5.CSF drainage poses a risk of harm to the participant. 6.Explicit refusal was obtained from both the subject and their family.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C3 complement protein level in cerebrospinal fluid;C1q complement protein level in cerebrospinal fluid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination (MMSE);Montreal Cognitive Assessment (MoCA);Hua Shan Auditory Verbal Learning Test;Digit Symbol Substitution Test (DSST);Forward and Backward Digit Span Test (DSFT, DFBT);Trail Making Test (TMT A and B);Stroop Color-Word Test;Verbal Fluency Test (VFT);Clock Drawing Test;Confusion Assessment Method for the Intensive Care Unit (CAM-ICU);Telephone Interview for Cognitive Status-Modified (TICS-M);Instrumental Activities of Daily Living Scale (IADL);Activities of Daily Living Scale (ADL); | — |
Countries
China
Contacts
Public ContactCao Xuezhao
The First Hospital of China Medical University
Outcome results
None listed