Valvular heart disease
Conditions
Interventions
Liposomal bupivacaine group:After induction of anesthesia and before surgical incision, ultrasound-guided pectoral nerves block type II (PECS II) and serratus anterior plane block (SAPB, at the fourth
Ropivacaine group:After induction of anesthesia and before surgical incision, ultrasound-guided pectoral nerves block type II (PECS II) and serratus anterior plane block (SAPB, at the fourth intercost
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years, BMI 18-35 kg/m²; 2. Planned elective right chest small incision valve surgery; 3. ASA II-III; 4. Planned to enter the standardized UFTA pathway; 5. Able to understand and complete the QoR-15 assessment.
Exclusion criteria
Exclusion criteria: 1. Allergy to amide local anesthetics/research drugs or a history of severe drug allergies; 2. Infection at the puncture site; 3. Severe coagulation disorders not meeting the safety requirements for blockade; 4. Long-term opioid use/chronic pain; 5. Severe liver, kidney, or respiratory dysfunction; 6. Emergency surgery/re-thoracotomy; 7. Combined procedures such as CABG or major aortic surgery; 8. Refusal of blockade.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Recovery-15 (QoR-15) total score on postoperative day 1 (POD1); | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to extubation;Cumulative opioid consumption within 0–72 hours (intravenous morphine milligram equivalents, MME);Pain burden within 0–72 hours (resting and dynamic NRS scores and NRS-AUC);QoR-15 total score on postoperative day 3 (POD3);Incidence of postoperative nausea and vomiting (PONV) and rescue antiemetic use within 0–24 hours;ICU length of stay;30-day postoperative outcomes (readmission, reintubation, and all-cause mortality); | — |
Countries
China
Contacts
Public ContactLeping Zhou
Zhejiang Provincial People's Hospital
Outcome results
None listed