crohn's disease
Conditions
Interventions
C group(physical examination group):Ciprofol ( modified sequential method ) + Remifentanil
D group(crohn 's disease group):Ciprofol ( modified sequential method ) + Remifentanil
Sponsors
Nanjing Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Gender : 18 ~ 64 years old, BMI : 18 ~ 30 kg / m^2, ASA grade : I or II ; 2. Patients and their families know the anesthesia, agree and sign the informed consent of anesthesia ; 3. Thirty patients in group C were included in the outpatient appointment for physical examination, and 30 patients in group D were included in the patients who had been diagnosed with Crohn 's disease. 4.Crohn 's disease group : ASA I ~ II ; aged 18-60 years old ; those who did not participate in other clinical trials within 3 months ; with Crohn 's disease, in a non-remission period ; there were no other systemic serious diseases.
Exclusion criteria
Exclusion criteria: 1. Combined with hearing impairment, heart, lung, liver and kidney and other important organs have organic lesions ; 2, Laryngeal, esophageal, gastric, duodenal surgery history, cardia achalasia ; 3. Long-term use of sedative hypnotics and psychotropic drugs ; 4, Long-term heavy drinking history ; 5, Recent history of severe allergies ; 6. Combined with respiratory diseases, such as symptoms disappeared less than a week of acute upper respiratory tract infection, snoring, asthma, etc. ; 7. History of adverse reactions of propofol anesthesia ; 8. Other intravenous anesthesia contraindications. 9.Crohn 's disease group:In the past week, there was a history of fever, upper infection or diarrhea ; penicillin skin test positive ; patients with gastrointestinal tract, severe liver and kidney function damage or other systemic diseases ; egg milk allergy ; family history of malignant high fever ; one week before the collection of specimens, antibiotics, steroids, Chinese herbal medicine or probiotics such as microecological preparations and yogurt were taken for non-surgical reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of body movement reactions during gastroscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions (Nausea and vomiting, bradycardia, hypotension, dizziness, respiratory depression );Vital signs ( BP, HR, SpO2, BIS );recovery time of consciousness;Dosage of cyclopophenol;Serum neurotransmitters ( glutamic acid, ?-aminobutyric acid, 5-hydroxytryptamine );Metabolite analysis of intestinal flora; | — |
Countries
China
Contacts
Public ContactDeng Youming
Nanjing Second Hospital
Outcome results
None listed