CRRT patients or VTE patients requiring heparin anticoagulation.
Conditions
Interventions
HLT-Guided Group:HLT Prediction Model-Based Individualized Heparin Anticoagulation
HLT-Guided Group:Empirical Heparin Anticoagulation
Test group:Heparin Loading Test (HLT)
Sponsors
Central Hospital of Dalian University of Technology Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Patients requiring continuous renal replacement therapy or diagnosed with venous thromboembolism and planned for unfractionated heparin anticoagulation.
Exclusion criteria
Exclusion criteria: 1. Patients at risk of bleeding; 2. Patients with coagulation disorders or positive lupus anticoagulant (APTT prolonged by 1.5 times or more); 3. Patients with severe liver failure; 4. Patients with a history of heparin allergy or heparin-induced thrombocytopenia (HIT); 5. Patients receiving thrombolytic therapy for venous thromboembolism (VTE).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to First APTT Target Attainment;The patient's APTT value 2 minutes after administration of the loading dose of heparin;APTT value at 30 minutes without heparin infusion;The patient's baseline APTT value before initiating the heparin infusion;Heparin infusion rate at the time of APTT goal attainment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Antithrombin III;Antiphospholipid antibodies;Coagulation Factor ?;Lupus anticoagulant parameter; | — |
Countries
China
Contacts
Public ContactRongli Yang
Central Hospital of Dalian University of Technology Hospital
Outcome results
None listed