None
Conditions
Interventions
Middle-aged group:Ciprofol TCI (Dixon sequential method)+ esketamine
Elderly Group:Ciprofol TCI (Dixon sequential method)+ esketamine
Sponsors
Affiliated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Age: 45 to 79 years old, no gender limitation; 2. Patients scheduled for elective surgery under general anesthesia with single-lumen endotracheal intubation; 3. ASA classification I to III; 4. 18.5 kg/m^2 < BMI < 30 kg/m^2; 5. Fully informed, voluntarily participating in this study, and signing the informed consent form personally.
Exclusion criteria
Exclusion criteria: 1.Severe cardiovascular and cerebrovascular diseases: New York Heart Association (NYHA) functional class >= III or left ventricular ejection fraction (LVEF) 100 bpm;; 3.Uncontrolled hypertension: preoperative resting blood pressure >= 160/100 mmHg; 4.Acute coronary syndrome or stroke within the previous 6 months; 5.Patients with untreated or inadequately treated hyperthyroidism; 6.Patients with a family history of malignant hyperthermia or at high risk of malignant hyperthermia (e.g., strabismus, scoliosis, etc.); 7.Difficult airway; 8.History of diabetes mellitus: HbA1c > 7.5%; 9.Abnormal hepatic and renal function: Child-Pugh score > 7, estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m^2; 10.History of allergic diseases, or hypersensitivity to the study drugs, soybeans, or eggs; 11.Pregnancy, lactation, or planned pregnancy in the near future; 12.Participation in other clinical trials of investigational drugs as a subject within the previous 3 months; 13.History of alcoholism or drug abuse; 14. Patients at high risk of severe intracranial hypertension, such as those with intracranial aneurysms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endotracheal intubation response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Saturation of Peripheral Oxygen ;The injection pain;The period from the start of anesthesia to the loss of consciousness of the subject (MOAA/S score <=1) ; | — |
Countries
China
Contacts
Public ContactLin Xiaofen
Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed