Stroke
Conditions
Interventions
Experimental group:Neurotranscranial magnetic stimulation combined with breathing training
Control group:Basic rehabilitation therapy combined with respiratory training
Sponsors
The First Affiliated Hospital of Henan Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Meets the diagnostic criteria of either "Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2023" or "Chinese Guidelines for the Diagnosis and Treatment of Cerebral Hemorrhage 2022", and is confirmed as acute stroke by head CT or MRI. 2.Glasgow Coma Scale (GCS) score: 5-8 points (indicating severe condition); 3.There is a respiratory dysfunction, manifested as forced vital capacity (FVC) being less than 60% of the predicted value or maximum inspiratory pressure (MIP) being less than -60 cmH2O (for males) or less than -45 cmH2O (for females). 4.Onset time of >= 48 hours and = 14 days; 5.The intracranial lesion (bleeding or infarction) has stabilized and has not progressed further. 6.Age: 18 - 75 years old; Vital signs are relatively stable: Systolic blood pressure 90 - 160 mmHg, heart rate 60 - 120 beats per minute (or maintained by medication), blood oxygen saturation (SpO2) >= 90% (under continuous oxygen inhalation condition); 7.The patient and their family members signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Including acute myocardial infarction, severe arrhythmia and other serious complications of the circulatory system; 2.There are electronic implant devices such as pacemakers and deep brain stimulators inside the body, or metal foreign objects within the skull; intracranial tumors and active intracranial infections. 3.History of epilepsy or family history of epilepsy, or having had an epileptic seizure before enrollment. 4.Scraped scalp, infection or severe skin diseases; 5.Combined with severe liver and kidney failure (Child-Pugh grade C, serum creatinine > 353.6 µmol/L and requiring dialysis), and severe metabolic diseases (such as uncontrolled diabetic ketoacidosis); 6.Expected survival period less than 2 weeks, or there is irreversible brain death / vegetative state; 7.Coagulation dysfunction or bleeding tendency, massive gastrointestinal bleeding; 8.Severe increase in ICP (greater than 20 mmHg) and uncontrolled; 9.Shock, unstable hemodynamics; 10.Newly developed rib fractures, severe pneumothorax, and mediastinal emphysema;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragm movement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypersensitive C-reactive protein;Forced vital capacity;Cough Peak Flow Rate (CPF);Diaphragmatic thickening ratio;Maximum inspiratory pressure;Arterial blood gas tests; | — |
Countries
China
Contacts
Public ContactZhang Haina
The First Affiliated Hospital of Henan Medical University
Outcome results
None listed