Postoperative delayed recovery of gastrointestinal function and postoperative nausea and vomiting
Conditions
Interventions
DEX Group (Trial Group):Dexmedetomidine: loading dose of 0.5 µg/kg over 15 minutes, followed by maintenance infusion of 0.1 µg/kg/h until 30 minutes before skin closure
saline control group received the same procedure but with normal saline.
Control Group:Normal saline: loading dose of 0.5 µg/kg over 15 minutes, followed by maintenance infusion of 0.1 µg/kg/h until 30 minutes before skin closure (simulated administration procedure).
Sponsors
Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
10 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients >10 years old with scoliosis who underwent lumbar long-segment spinal fusion surgery under general anesthesia. 2.ASA is graded as I~III; 3.Pass the ethics review and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients with recent or previous gastrointestinal diseases, cardiovascular diseases, respiratory diseases and/or central nervous system diseases, severe liver and kidney dysfunction, mental illness or severe audio-visual dysfunction who cannot cooperate with the study; 2.Patients who are allergic to dexmedetomidine or other anesthetic drugs, or who are preoperatively prescribed antihypertensive drugs containing clonidine or alpha 2-adrenergic receptor agonists. 3.Patients with simple thoracic scoliosis with higher parietal spine (including those undergoing selective thoracic spinal fusion); 4.Preoperative use of opioids, bradycardia (heart rate < 50 beats/min), and cardiac block greater than grade 1;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first flatus within 48 hours postoperatively;Time to first defecation within 48 hours postoperatively;Time to first intake of food within 48 hours postoperatively;Incidence of adverse events including nausea, vomiting, and dizziness within 48 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum motilin level before surgery;Serum motilin level at 24 hours postoperatively; | — |
Countries
China
Contacts
Public ContactZhang Wei
Drum Tower Hospital
Outcome results
None listed