obstructive sleep-disordered breathing, oSDB
Conditions
Interventions
active drug group:Inhalation of dexmedetomidine + esketamine
placebo group:Inhale an equal amount of normal saline
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1.Age: 3 - 7 years old 2.The patient is scheduled to undergo adenoidectomy and tonsillectomy (or simple tonsillectomy) under general anesthesia 3.The guardian has signed the informed consent form
Exclusion criteria
Exclusion criteria: 1.Due to nasal diseases (such as rhinitis, nasal polyps, or any condition causing nasal congestion), nasal administration is not suitable 2.Children have diagnosed cardiovascular and respiratory diseases 3.Children have delayed neurological development or have visual or hearing impairments affecting communication 4.Post-traumatic brain injury or after neurosurgery 5.Abnormal liver and kidney function (more than twice the upper limit of normal values) 6.ASA classification = III 7.The child's BMI is above the 95th percentile of the age and gender standard 8.Allergic to dexmedetomidine and/or esketamine, or other situations deemed by the researchers not suitable for inclusion in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The FLACC score within 48 hours after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hospital stay;PACU residence time;The incidence of adverse events during the stay in the PACU;Postoperative analgesic drugs;PACU residence time;The incidence of complications 30 days after the surgery;The NRS scores for sleep during the first three nights after the surgery;Postoperative extubation time; | — |
Countries
China
Contacts
Public ContactDing Ting
Peking University First Hospital
Outcome results
None listed