Sepsis
Conditions
Interventions
Observation group (Patients with sepsis, including septic shock):None
Control group:None
Sponsors
Baotou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Meet the diagnostic criteria for sepsis as defined in the "International Consensus on the Third Edition of Sepsis and Septic Shock" (Sepsis-3), that is, after a clear or highly suspected infection, the Sequential Organ Failure Assessment (SOFA) score increases by = 2 points compared to the baseline; 3. Patients who is hospitalized in the intensive care unit (ICU) or a related critical care ward, and has received standardized comprehensive treatment in accordance with the current guidelines for sepsis management; 4. With complete clinical data and follow-up information, it is possible to assess whether secondary infections occurred during hospitalization and within 28 days, as well as related clinical outcomes. 5. The subjects themselves or their legal representatives signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Age < 18 years old; 2. Patients with clearly identified severe underlying diseases that may significantly affect immune status or survival prognosis, such as advanced malignant tumors, end-stage liver disease or end-stage kidney disease; 3. Patients with clearly diagnosed hematological diseases or autoimmune disorders; 4. Patients who have been receiving immunosuppressive therapy for a long time (such as long-term high-dose glucocorticoids or immunosuppressants); 5. Patients who cannot obtain complete clinical data or cannot complete the collection of research-related samples.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bulk RNA-seq of PBMC;Single-cell RNA-seq of PBMC;Landscape of plasma lncRNA;Proteome of plasma; | — |
Countries
China
Contacts
Public ContactXu Teng
Baotou Central Hospital
Outcome results
None listed