Persistent pulmonary hypertension of newborn
Conditions
Interventions
Severe cases treated with iNO under ultrasound guidance:Severe cases treated with iNO under ultrasound guidance
Conventional iNO treatment group:Conventional iNO treatment
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 7 Days
Inclusion criteria
Inclusion criteria: (1) Gestational age at birth >=34 weeks and postnatal age =0.6 and OI >=16; (4) Family consent obtained for iNO treatment of PPHN; (5) Parental consent obtained to participate in this study.
Exclusion criteria
Exclusion criteria: (1) Complex congenital heart disease, ductus arteriosus-dependent congenital heart disease, or congestive heart failure; (2) severe congenital malformations or chromosomal disorders; (3) severe pulmonary dysplasia; (4) congenital methemoglobinemia; (5) severe hemorrhage, such as intracranial hemorrhage, intraventricular hemorrhage, or pulmonary hemorrhage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| iNO usage time;PPHN treatment effectiveness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of rebound hypoxemia;Discharge Outcome;Mechanical ventilation duration;Oxygen therapy duration;Duration of vasoactive substance use;Maximum Vasoactive Substance Index; | — |
Countries
China
Contacts
Public ContactJianhui Wang
Children's Hospital of Chongqing Medical University
Outcome results
None listed