Upper Tract Urothelial Carcinoma
Conditions
Interventions
Gold Standard:Surgical histopathology
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Patients clinically diagnosed with malignant tumor of the renal pelvis or ureter (UTUC) by means such as ultrasound, CT urography (CTU), magnetic resonance imaging (MRI), ureteroscopy with or without biopsy pathology, or cytology/urine methylation testing; (2) Age: 18–85 years; (3) Assessed as high-risk UTUC according to guidelines, meeting at least one of the following criteria: a. Presence of hydronephrosis; b. Tumor diameter >= 2 cm; c. Cytology indicating high-grade tumor; d. Ureterorenoscopic biopsy indicating high-grade tumor; e. Multifocal tumor; f. Prior radical cystectomy for high-grade bladder cancer; g. Presence of multiple histological subtypes; h. CT findings suggestive of invasive tumor growth (cT2–cT4). Or imaging findings do not exclude regional lymph node metastasis (cN+); (4) Voluntarily agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Explicitly refuse to undergo radical nephroureterectomy with bladder cuff excision and regional lymphadenectomy on the affected side; (2) Have claustrophobia or other conditions that preclude completion of the examination; (3) Patients with alcohol or drug abuse, or those with mental disorders who are unable to cooperate; (4) Concurrent diagnosis of other malignant tumors; (5) Poor general condition that prevents completion of PET/CT examination or inability to tolerate surgery; (6) Mental abnormalities or intellectual disability with poor compliance, resulting in inability to cooperate with examinations and treatment; (7) Women who are pregnant, lactating, or planning to become pregnant within six months; (8) Other circumstances deemed by the clinical trial personnel as inappropriate for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| diagnostic sensitivity;diagnostic specificity; | — |
Countries
China
Contacts
Public ContactJianye Liu
The Third Xiangya Hospital of Central South University
Outcome results
None listed