Postoperative rebound pain after shoulder arthroscopy
Conditions
Interventions
Trial Group:Intravenous esketamine (0.2 mg/kg IV bolus + 0.1 mg/kg/h infusion) during surgery
Control Group:Isotonic saline in equivalent volume
Sponsors
Jinan Third People's Hospital, Shandong Province
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–65 years, either gender, ASA physical status I–III; 2. Scheduled for arthroscopic shoulder surgery; 3. Anesthesia technique: general anesthesia combined with brachial plexus block; 4. Voluntary participation in this study and signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with known hypersensitivity to esketamine or any of its components. 2. Hepatic or renal dysfunction. 3. Severe cardiovascular or cerebrovascular diseases, such as grade III hypertension, severe valvular heart disease, chronic heart failure, severe arrhythmia, ischemic heart disease, and symptomatic stroke. 4. Patients at high risk of elevated intracranial pressure. 5. Untreated or inadequately treated hyperthyroidism. 6. Patients who require additional surgery during the study, or develop complications intraoperatively or postoperatively that may affect study evaluations. 7. Patients unwilling to participate after being informed of the study details. 8. Infection at the puncture site. 9. Coagulation disorders. 10. Patients with a history of severe psychiatric disorders or current severe psychiatric illness. 11. Patients who fail to understand or complete the Numerical Rating Scale (NRS), patient-controlled analgesia (PCA) pump operation, telephone interviews, or the Neuropathic Pain Symptom Inventory (NPSI) during pre-enrollment assessment will be excluded. 12. Pregnant or lactating women. 13. Individuals who have participated in other clinical trials within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of rebound pain at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores at various time points;Cumulative analgesic consumption at different time points;Time from interscalene brachial plexus block to first as-needed opioid use;Number of rescue analgesia administrations within 48 hours postoperatively; | — |
Countries
China
Contacts
Public ContactZheng Zhenzhen
Jinan Third People's Hospital, Shandong Province
Outcome results
None listed