None
Conditions
Interventions
Experimental Group 1:Email notification to editors in Phase 1 and an escalated intervention will be employed to send the email to their authors in Phase 2
Experimental Group 2:Email notification to authors in Phase 1 and an escalated intervention will be employed to send the email to their editors in Phase 2
Group 3 Control Group:No interventions in Phase 1 and an escalated intervention will be employed to send the email to both editors and authors in Phase 2
Sponsors
Anhui Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: We will identify eligible SRs (contaminated SRs) that meet all of the following inclusion criteria: 1.SRs that synthesize at least one retracted trial in evidence synthesis; 2.SRs focused on healthcare interventions; 3.No correction action regarding the retracted trials prior to randomization, such as correction, and updating; 4.Updated version remaining to synthesize retracted trials (e.g., Cochrane reviews).
Exclusion criteria
Exclusion criteria: And, contaminated SRs will be excluded if reviews meet any of the exclusion criteria: 1.SRs themselves have been retracted; 2.Retracted trials having been removed in the latest version of targeted SRs and conclusion having been updated accordingly; 3.SRs labelled as an expression of concern by editors; 4.Evidence used for meta-regression analysis and other reproducibility study (e.g., umbrella reviews), due to burden of replication to these studies; 5.SRs published on pre-print websites (e.g., medRxiv); 6.SRs published in non-English languages; 7.SRs published as short reports or conference abstracts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is a composite endpoint comprising correction, update, and retraction of SRs. ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correction for flawed evidence from retarcted trials;Updates to flawed evidence from retarcted trials;Retraction of systematic reviews;Time to expression of concerns;Response rate to emails;Censoring for repair contamination after removal of flawed evidence:; | — |
Countries
China
Contacts
Public ContactZhen Peng
Anhui Medical University
Outcome results
None listed