Postoperative delirium
Conditions
Interventions
The transcutaneous auricular vagus nerve stimulation group (taVNS) group:Place the stimulating electrode on the concha subvessel and another ear clip to the earlobe.
Control group:Two electrode clamps attached to the earlobe and the helix respectively
Sponsors
Hebei General Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients aged >= 60; 2. ASA grade II or III; 3. Scheduled for elective lower extremity orthopedic surgery.
Exclusion criteria
Exclusion criteria: 1.Refuse to participate; 2.Preoperative cognitive impairment, defined as an MMSE score below education-adjustedcutoffs (<=17 for illiterate, <=20 for primary school, <=22 for middleschool, and<=23 for high school/college), based on previouslyvalidated normative and epidemiological evidence accountingfor the influence of education ; 3.Local auricular skin issues (rash, infection, lesions, ulcers, scars) 4.Patients with contraindications for taVNS, including implanted cardiac devices, a history of seizures, bleeding diathesis, or current anticoagulant use 5.Preoperative sinus bradycardia (HR < 60 bpm) and severe cardiovascular or cerebrovascular disease; 6.Airway hyperresponsiveness exists (e.g., asthma, chronic obstructive ventilatory dysfunction) 7.Pregnancy, or unable to cooperate with treatment; 8.Use of antibiotics, probiotics or prebiotics within 3 months before surgery; 9.History of gastrointestinal surgery, gastrointestinal disorders (e.g., peptic ulcer, diarrhea, or gastric bleeding).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota;Neutrophil extracellular trap biomarkers;Postoperative gastrointestinal function indicators; | — |
Countries
China
Contacts
Public ContactZhang Meng
Hebei General Hospital
Outcome results
None listed