Postoperative Nausea and Vomiting
Conditions
Interventions
Control group:30% Inspired Oxygen Fractions during operation
Experimental group:80% Inspired Oxygen Fractions during operation
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18–65 years (2) ASA physical status: I–II (3) Patients scheduled for elective orthopedic surgery under general anesthesia, including: (4) Spine surgery: involving procedures of the cervical, thoracic, and lumbar spine, etc. (5) Joint surgery: including open or arthroscopic procedures of the ankle, knee, hip, shoulder, elbow, etc.
Exclusion criteria
Exclusion criteria: (1) Severe cardiopulmonary or cerebral diseases: chronic obstructive pulmonary disease (COPD, GOLD stage = 3); pulmonary hypertension (mPAP = 25 mmHg); uncontrolled heart failure (NYHA class = III); history of myocardial infarction or cerebral infarction. (2) Special populations: pregnant or lactating women; patients undergoing emergency surgery; patients who received antiemetic medications (e.g., tropisetron, dexamethasone) or steroids within 24 hours preoperatively; patients requiring beach chair or sitting positions during surgery. (3) Other confounding factors: history of drug or alcohol dependence; severe psychiatric disorders or communication barriers; known allergy to any anesthetic agents used in the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of postoperative nausea and vomiting within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of postoperative nausea;Incidence of postoperative severe vomiting;Incidence of postoperative adverse events; | — |
Countries
China
Contacts
Public ContactQiong Yu
Huashan Hospital, Fudan University
Outcome results
None listed