cerebrovascular stenosis or unruptured high-risk intracranial aneurysm
Conditions
Interventions
Control group:Anesthesia was induced with 0.3 µg/kg sufentanil, 1.5–2 mg/kg propofol, and 0.6 mg/kg rocuronium. Anesthesia was maintained with continuous infusions of remifentanil and propofol to main
Experimental Group:Anesthesia was induced with 0.3 µg/kg sufentanil, 0.3–0.4 mg/kg ciprofol, and 0.6 mg/kg rocuronium. Anesthesia was maintained with continuous infusions of remifentanil and ciprofol
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years old; 2. Diagnosed with cerebrovascular stenosis or unruptured high-risk intracranial aneurysm by DSA or CTA; 3. Elective cerebrovascular stent placement or intracranial aneurysm embolization; 4. Signed informed consent form
Exclusion criteria
Exclusion criteria: 1. Emergency neurointerventional surgery; 2. Patient has a history of severe cardiovascular and pulmonary disease; 3. Severe liver and kidney dysfunction; 4. Anticipated difficult airway or difficulty with postoperative extubation; 5. Comorbid morbid obesity, defined as BMI >= 35 kg/m^2; 6. Allergy to contrast agents or general anesthetics; 7. Difficulty in preoperative communication and interaction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the curve of MAP relative to baseline MAP during anesthesia induction and maintenance.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time-weighted average of AUC-bMAP (TWA-bMAP);coefficient of variation (CV) of MAP;average real variability (ARV) of MAP;incidence of hypotension;lowest MAP;cumulative dose of vasopressors;postoperative recovery parameters (extubation time, awakening time, length of hospital stay); | — |
Countries
China
Contacts
Public ContactHan Ruquan
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed