Neurodevelopmental Disorders
Conditions
Interventions
Experimental group:Infuse normal saline containing 0.2 µg/mL dexmedetomidine at an infusion rate of 1 mL/kg/h
Control group:Normal saline was infused at a rate of 1 mL/kg/h intraoperatively.
Sponsors
Hunan Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: Patients aged 0 to 12 months who were scheduled to undergo two or more abdominal surgeries, with a single anesthesia duration exceeding 1 hour, and who received operations at Hunan Children's Hospital were enrolled.
Exclusion criteria
Exclusion criteria: Preterm infants (corrected gestational age < 37 weeks at the time of surgery), ASA physical status class ? or above, history of severe intrauterine hypoxia and asphyxia at birth, central nervous system diseases, severe hepatic and renal dysfunction, history of prior opioid use, history of prior inhalation anesthesia and sedation, contraindications to caudal anesthesia, contraindications to the use of dexmedetomidine (DEX), sevoflurane, cisatracurium and ropivacaine, as well as postoperative admission to the intensive care unit or requirement for mechanical ventilation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ASQ-3,Ages & Stages Questionnaire- 3rd Edition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical growth indicators; | — |
Countries
China
Contacts
Public ContactDu Zhen
Hunan Children's Hospital
Outcome results
None listed