None
Conditions
Interventions
A Group :Midazolam orally administered + Dexmedetomidine administered by nasal drip
B Group:Oral chloral hydrate + Intranasal dexmedetomidine
Sponsors
Jiaxing Maternity and Child Health Care Hospital
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Children who require sedation for planned MRI examinations; 2. Patients aged 2–6 years who cannot cooperate; 3. ASAI-II grade, non-cyanotic congenital heart disease patients; 4. Sedation administered by an anesthesiologist; 5. Guardians of the patients voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Children known to be allergic to midazolam, dexmedetomidine, chloral hydrate, or other drugs used; 2. Children with intellectual or cognitive impairments who cannot complete the corresponding assessments (brain injury, cerebral softening, cerebral necrosis, intellectual disability, genetic diseases, various syndromes accompanied by developmental disorders); 3. Children who have used sedative-hypnotic drugs in the past 24 hours; 4. Children who are excessively obese, with a body mass index (BMI) = 23.9 kg/m²; 5. Children who cannot take oral medication due to their own medical conditions; 6. Children who refuse to participate in the study; 7. Children with a history of multiple sedations; 8. Children who have slept within the past 2 hours; 9. Children with acute upper respiratory infections showing catarrhal symptoms; 10. Children who have experienced sleep deprivation; 11. Children with a Ramsay score > 3 at the time of assessment; 12. Children whose examination lasts longer than 30 minutes; 13. Children who experience serious adverse reactions during the study and need to withdraw from intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of sedation after completing the examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| onset time;recovery time;Incidence of adverse events (increased/decreased heart rate, respiratory depression/ apnea, choking cough, mental abnormalities, nausea, vomiting, drowsiness, vertigo, skin itching, etc.); | — |
Countries
China
Contacts
Public ContactYao Hanqing
Jiaxing Maternity and Child Health Care Hospital
Outcome results
None listed