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Clinical study on the prevention of adverse reactions related to carboprost tromethamine during cesarean section under spinal anesthesia by nalbuphine hydrochloride

Clinical study on the prevention of adverse reactions related to carboprost tromethamine during cesarean section under spinal anesthesia by nalbuphine hydrochloride

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600121355
Enrollment
Unknown
Registered
2026-03-30
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chest distress

Interventions

Experimental group:Nalbuphine was administered intravenously

Sponsors

Wuxi Huishan District People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) American Society of Anesthesiologists (ASA) grade II-III. (2) singleton full-term pregnancy (>=37 weeks); (3) Cesarean section under spinal anesthesia (or combined spinal-epidural anesthesia). (4) Informed consent was signed. (5) Age 20-40 years old.

Exclusion criteria

Exclusion criteria: (1) Allergic to nalbuphine, opioids or carboprost. (2) History of severe gestational hypertension, heart disease, asthma, or glaucoma; (3) Fetal distress, placenta previa, placental abruption and other situations requiring emergency delivery of the fetus. (4) patients had nausea, vomiting or used antiemetic drugs before surgery. (5) patients had a history of opioid abuse or long-term use of analgesics. (6) severe abnormal liver function (anesthesiologists judged that nalbuphine was not suitable for use).

Design outcomes

Primary

MeasureTime frame
Chest distress;

Secondary

MeasureTime frame
Nausea and vomiting;Blood pressure;Heart rate;Dyspnea;Postoperative pain;

Countries

China

Contacts

Public ContactYu Zhiyang

Wuxi Huishan District People's Hospital

doctoryuzhiyang@163.com+86 136 4515 5409

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026