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The role and mechanism of E3 ubiquitin ligase Cbl-b in regulatingmicroglial NLRP3 inflammasome via DBC1/SIRT1 axis on perioperativeneurocognitive disorders in aged

The role and mechanism of E3 ubiquitin ligase Cbl-b in regulatingmicroglial NLRP3 inflammasome via DBC1/SIRT1 axis on perioperativeneurocognitive disorders in aged

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600121331
Enrollment
Unknown
Registered
2026-03-30
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative neurocognitive disorders

Interventions

PND Group:None

Sponsors

The Second Affiliated Hospital of Nanchang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: Elderly patients (aged =65 years) undergoing elective total hip arthroplasty under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Failed preoperative anesthesia assessment. 2. Long-term use of other opioids or analgesics. 3. Comorbid kidney or liver diseases, infectious diseases, or psychological disorders. 4. History of alcohol abuse or substance abuse.

Design outcomes

Primary

MeasureTime frame
Cbl-b Express;SIRT1 Express;DBC1 Express;NLRP3 Express;—

Countries

china

Contacts

Public ContactYong Chen

The Second Affiliated Hospital of Nanchang University

chenyongdaniel@126.com+86 791 8620 9562

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 17, 2026