Gynecologic cancers (GCs)
Conditions
Interventions
External Group:None
Internal Group:None
Sponsors
Affiliated Qingyuan Hospital, Guangzhou Medical University (Qingyuan People's Hospital)
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosed with primary gynecological malignancy (including cervical cancer, ovarian cancer, endometrial cancer, etc.) confirmed by histopathology; 2. Age >= 18 years; 3. Scheduled to receive first-time chemotherapy regimens containing platinum-based agents and/or taxanes, such as neoadjuvant or adjuvant chemotherapy; 4. Completed at least 3 cycles of chemotherapy with complete blood routine monitoring data; 5. Complete blood routine and biochemical test results available within one week prior to chemotherapy.
Exclusion criteria
Exclusion criteria: 1. Presence of grade II or higher myelosuppression prior to chemotherapy (according to CTCAE v5.0 criteria); 2. Concurrent other primary malignancies or previous history of chemotherapy or radiotherapy; 3. Coexisting severe hematologic diseases (e.g., aplastic anemia, myelodysplastic syndrome, etc.); 4. Coexisting severe hepatic or renal dysfunction (Child – Pugh class C, or eGFR < 30 mL/min/1.73 m²); 5. Active infection or uncontrolled autoimmune disease; 6. Anticipated inability to collect complete clinical data;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prognostic Nutritional Index(PNI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory parameters: serum albumin, hemoglobin, neutrophil count, peripheral blood lymphocyte count, platelet count.;Disease and treatment data: tumor type, FIGO stage, tumor diameter (longest), distant metastasis (yes/no), chemotherapy regimen (drug, dose, cycle), surgery before chemotherapy (yes/no).;The model evaluation metrics include discrimination, calibration, and clinical utility.; | — |
Countries
China
Contacts
Public ContactCaifang Wang
Affiliated Qingyuan Hospital, Guangzhou Medical University (Qingyuan People's Hospital)
Outcome results
None listed