Seeking differences in treatment outcomes among different non-union limbs under a unified mixed bone grafting scheme.

A Study on the Efficacy of BMP-2-loaded Calcium Phosphate Combined with Antibiotic-loaded Calcium Phosphate Artificial Bone in Treating Infection-related Nonunion at Different Sites

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600121310

Enrollment

Unknown

Registered

2026-03-27

Start date

2026-03-27

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bone healing and infection

Interventions

Tibia of the lower limb:None

Upper arm humerus:None

Lower extremity femur:None

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Admissions from January 2025 to December 2026; 2. Diagnosed with infectious nonunion, the infected site is the humerus of the upper limb, or the tibia or femur of the lower limb. 3. Age 18-70 years; 4. Treatment with Calcium Phosphate Carrier-Loaded Recombinant Human BMP-2 and Antibiotic-Loaded Calcium Phosphate Synthetic Bone; 5. Complete clinical data.

Exclusion criteria

Exclusion criteria: 1. Severe dysfunction of vital organs such as heart, liver, and kidneys; 2. Mental illness, cognitive disorders, etc., unable to cooperate with treatment and follow-up; 3. Bone defect length > 6 cm or area > 20 cm², difficult to reconstruct.

Design outcomes

Primary

Measure	Time frame
Infection Control Effectiveness;Bone healing status;	—

Secondary

Measure	Time frame
Difficulty of infection control in different parts;Bone healing time in different parts;Clinical functional recovery;	—

Countries

China

Contacts

Public ContactZhou Longze

Yuebei People’s Hospital

493461793@qq.com+86 751 691 3623

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 4, 2026