Ischemia-reperfusion injury
Conditions
Interventions
Lidocaine group(L):Fifteen minutes before the start of portal occlusion, a loading dose of lidocaine of 1.5 mg/kg (based on ideal body weight) is administered intravenously. This is followed by a cont
Control group:Administer the same volume of physiological saline.
Sponsors
Fudan University Shanghai Cancer Center (Pudong Campus)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Signed informed consent form; 2.18 years =< Patient age <=75 years , regardless of gender; 3. American Society of Anesthesiologists (ASA) classification I or II; 4.Preoperative Child-Pugh score A or B; 5.Patients scheduled for elective liver tumor resection; 6.Patients expected to undergo intraoperative hepatic portal occlusion.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2.Sick sinus syndrome, severe sinus bradycardia (heart rate < 50 bpm), second-degree or higher atrioventricular block without a pacemaker; 3. Known allergy to the study drug; 4.Patient refuses to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma interleukin-6 (IL-6) concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma tumor necrosis factor-alpha (TNF-a) as a marker of inflammation and injury;Plasma interleukin-10 (IL-10) as a marker of inflammation and injury;Lactate level;Creatinine level;Pain assessment (VAS score at rest/coughing);Opioid consumption (total morphine equivalent dose within 48 hours postoperatively);Gastrointestinal recovery (time to first flatus or bowel movement);Postoperative complications (Clavien-Dindo classification);Hospital length of stay (from surgery date to discharge criteria met);Quality of life assessment (QoR-15 questionnaire); | — |
Countries
China
Contacts
Public ContactZhu Yun
Fudan University Shanghai Cancer Center (Pudong Campus)
Outcome results
None listed