Mild cognitive impairment
Conditions
Interventions
Individualized Target Group:MRI-guided individualized precise target iTBS
Conventional Target Group:iTBS targeted localization based on the 10-20 EEG system
Healthy Control Group:None
Sponsors
The People’s Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients who meet the diagnostic criteria for MCI, and the healthy control with the normal performance in neuropsychological test; 2.Age range: 55-75 years old; 3.Right-handed; 4.No language communication barriers, able to cooperate in completing neuropsychological scale assessments.
Exclusion criteria
Exclusion criteria: 1.Dementia; 2.Central nervous system diseases such as cerebrovascular disease, Parkinson's disease, encephalitis, epilepsy, brain tumors, traumatic brain injury, etc; 3.Systemic diseases known to cause cognitive impairment, such as hypothyroidism, VB12 or folate deficiency, neurosyphilis, HIV infection, severe anemia, hepatic encephalopathy, carbon monoxide poisoning, etc; 4.History of mental illness in the past; 5.Material factors such as drug abuse; 6.Related risk factors, such as hypertension history, hyperlipidemia history, diabetes history, smoking and drinking history; 7.Patients who have used other drugs that may cause cognitive function changes or important organ failure such as heart, brain, and kidneys before inclusion; 8.Those who cannot cooperate to complete the corresponding evaluation and inspection and withdraw midway; 9.Contraindications for magnetic resonance imaging (such as metal dentures or other metal implants that cannot be removed, claustrophobia, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain function changes such as hippocampal-cortical network functional connectivity strength;global cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biomarkers;changes in mutimodal MRI such as grey matter volume,cortical thickness,etc.;Incidence of adverse events;Cognitive function; | — |
Countries
China
Contacts
Public ContactDemao Deng
The People’s Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed