Cognitive dysfunction
Conditions
Interventions
Propofol group (group P):During anesthesia induction, sodium fospropofol is slowly administered intravenously at 10–12 mg/kg. During anesthesia maintenance, sodium fospropofol
Phosphorylated propofol disodium group (Group F):During the induction of anesthesia, propofol disodium was slowly injected intravenously at a dose of 10-12 mg/kg. During the maintenance of anesthesia
Sponsors
The Second People's Hospital of Yibin City
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patient age 45–65 years; 2. American Society of Anesthesiologists (ASA) classification II–III; 3. Elective laparoscopic total hysterectomy (+/- adnexectomy); 4. Body Mass Index (BMI) 18–30 kg/m^2; 5. Subjects provide informed consent before the experiment and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of severe cardiovascular or pulmonary diseases; 2. Preoperative dementia, mental illness, or cognitive impairment; 3. Presence of diseases causing communication disorders; 4. Severe cardiovascular diseases (uncontrolled hypertension, NYHA class = III, LVEF 2 times the upper limit of normal, eGFR < 60 mL/min/1.73m^2); 6. History of long-term use of nonsteroidal anti-inflammatory drugs or opioid analgesics; 7. Use of other analgesic or sedative drugs within 24 hours before surgery; 8. Expected intraoperative blood loss greater than 15 mL/kg or requiring blood transfusion; 9. Planned postoperative admission to ICU; 10. Currently pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and duration of hypotension ;Time to emergence and extubation;Duration of PACU stay;Rest/activity VAS pain scores at 24 and 48 hours postoperatively;Number of effective PCIA compressions;Incidence of postoperative nausea and vomiting and rescue analgesia rate;Length of hospital stay;Anesthesia satisfaction score; | — |
Countries
China
Contacts
Public ContactDeshui Yu
The Second People's Hospital of Yibin City
Outcome results
None listed