Anesthesia for short-duration hysteroscopic surgery
Conditions
Interventions
Trial Group:Induction: Tegeline 10µg/kg infusion over 10 minutes + Remazolam 0.3mg/kg intravenous injection
Maintenance: Remazolam 1mg/kg/h continuous intravenous infusion. Intraoperative rescue: Add Tegeline 0.25mg for movement, manage respiratory depression according to standard protocol.
Control Group:Induction: Sufentanil 0.1µg/kg intravenous injection + Propofol 2mg/kg intravenous injection
Maintenance: Propofol 6mg/kg/h continuous intravenous infusion. Intraoperative rescue: Add Sufentanil 0.05µg/kg for movement. Both groups received pre-treatment with Oubai 4mg + Ketorolac 30mg intrave
Sponsors
Maternal and Child Health Hospital of Jiangxi Province
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Aged 18–65 years, ASA physical status I–III; 2. Scheduled for hysteroscopic surgery, including endometrial polypectomy, submucous myomectomy, cervical polyp resection, intrauterine device removal, etc.; 3. Expected operative duration = 30 minutes; 4. Patients and their families provided informed consent and signed the informed consent form; 5. No history of drug allergy (no allergy to study or control drugs).
Exclusion criteria
Exclusion criteria: 1. Severe hepatic or renal dysfunction (Child-Pugh class C liver dysfunction, creatinine clearance < 30 mL/min); 2. Coagulation disorders; 3. Severe cardiovascular diseases (e.g., heart failure, severe arrhythmia, uncontrolled hypertension, etc.); 4. Psychiatric disorders or cognitive impairment that prevent cooperation with the study; 5. Pregnant or lactating women; 6. Recent use (within 1 month) of strong inhibitors of CYP3A4/CYP2D6 (e.g., paroxetine).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative awakening time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative movement;Incidence of adverse events including intraoperative respiratory depression, postoperative nausea, and postoperative vomiting;Hemodynamic stability during surgery (changes in systolic blood pressure, diastolic blood pressure, and heart rate);Patient satisfaction with anesthesia; | — |
Countries
China
Contacts
Public ContactLi Huanhuan
Jiangxi Maternal and Child Health Hospital
Outcome results
None listed