Colonic spasm and colorectal polyps
Conditions
Interventions
Experimental group:Endoscopic irrigation with a novel endoscopic irrigation solution (0.1% menthol solution combined with dimethyl silicone oil suspension)
Control group:Endoscopic irrigation with normal saline
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Ages 18–75 years, both sexes/gender not limited; 2.Planned for colonoscopy (for screening, diagnostic, or follow-up purposes); 3.Adequate bowel preparation quality (Boston Bowel Preparation Scale score >= 6); 4.Voluntarily signed informed consent and is able to cooperate in completing study-related assessments.
Exclusion criteria
Exclusion criteria: 1.Allergic to menthol, cyclodextrin, or related substances; 2.History of severe intestinal diseases (such as ulcerative colitis, Crohn’s disease, intestinal perforation, intestinal obstruction, intestinal tumors, etc.); 3.With combined severe dysfunction of major organs such as the heart, liver, kidneys, or lungs, or coagulation disorders; 4.Pregnant or lactating women; 5.Those who have used anticholinergic drugs, calcium channel blockers, or other antispasmodic medications within one week prior to the examination; 6.Individuals with mental illness or cognitive impairment that prevents them from cooperating with the study; 7.Those with a history of contraindications to colonoscopy or serious adverse reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adenoma detection rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Spasm inhibition rate;Incidence of intestinal spasm;Polyp Detection Rate;Cecal intubation time, withdrawal time;Intravenous Antispasmodic Drug Usage Rate; | — |
Countries
China
Contacts
Public ContactJianning Yao
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed