Adolescent bipolar disorder
Conditions
Interventions
NSSI Group:Modified Electroconvulsive Therapy (MECT), one course (8-12 sessions)
standardized anesthesia (propofol/mid-long chain fat emulsion, succinylcholine, atropine sulfate)
mood stabilizers not recommended during treatment
if low-dose use occurs, normalized using chlorpromazine (CPZ) equivalent or defined daily dose (DDD) method
otherwise, standard inpatient treatment and care (TAU).
Non-NSSI Group:Modified Electroconvulsive Therapy (MECT), one course (8-12 sessions)
Sponsors
JiangXi Mental Health Center
Eligibility
Sex/Gender
All
Age
10 Years to 19 Years
Inclusion criteria
Inclusion criteria: 1. After a structured clinical interview (Mini-Plus) conducted by at least two psychiatrists, participants were assigned to the NSSI group if they met the DSM-5 diagnostic criteria for NSSI and reported five or more qualifying self-injurious episodes in the past year. Those with fewer than five qualifying episodes or whose behaviors did not meet the diagnostic criteria were included in the non-NSSI group. 2. All patients met the ICD-10 diagnostic criteria for bipolar disorder, were in an acute phase of the illness, and had a score >20 on the 24-item Hamilton Depression Rating Scale (HAMD-24) and/or >10 on the Young Mania Rating Scale (YMRS). 3. The patients were diagnosed as eligible for and in need of modified electroconvulsive therapy (MECT). 4. Participants were either first-diagnosed and medication-naïve for bipolar disorder, or had been off relevant medications for at least three months prior to the study. 5. All participants were right-handed and aged between 10 and 19 years. 6. Both patients and their legal guardians provided informed consent and agreed to participate voluntarily. 7. Participants agreed to complete a researcher-developed questionnaire covering general information, suicidal ideation, and related behaviors.
Exclusion criteria
Exclusion criteria: 1. Exclusion of patients with clear and severe suicidal intent or suicidal behavior; 2. Exclusion of patients with other major psychiatric disorders (e.g., schizophrenia, delusional disorder) or personality disorders accompanied by self-injury or suicidal behavior; 3. Exclusion of patients with organic brain disease, severe physical illness, psychoactive substance dependence, stress-related disorders, or emotional problems secondary to other organic conditions; 4. Exclusion of individuals who had taken psychoactive substances prior to testing, or who had conditions such as hypertension, diabetes, or other organic factors that would preclude safe participation in cognitive testing or blood sampling.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total score of the Adolescent Non-Suicidal Self-Injury Questionnaire (ANSAQ);Ottawa Self-Harm Inventory (OSI) score;Brief Electroconvulsive Therapy Cognitive Screening Scale (BECS) score;Electroconvulsive Therapy Cognitive Assessment Tool (ECCA) score;Hamilton Depression Rating Scale (HAMD-24) total score;Young Mania Rating Scale (YMRS) total score;THINC-it cognitive test score index (Z-score); | — |
Countries
China
Contacts
Public ContactZhang Jing
JiangXi Mental Health Center
Outcome results
None listed