Depression, treatment-resistant depression
Conditions
Interventions
Sponsors
Shandong mental health center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. With approval from the hospital's ethics committee, all participants (patients' families) signed informed consent forms. 2. 100 cases of treatment-resistant major depressive disorder patients meeting DSM-5 diagnostic criteria were enrolled. 3. Age range: 18-65 years, both genders. 4. Hamilton Depression Rating Scale (HAMD) score >=24, and Montgomery–Asberg Depression Rating Scale (MADRS) score >=20. 5. Stable antidepressant treatment regimen maintained. 6. Maudsley Staging Method (MSM): Moderate to severe treatment resistance, MSM score >=7.
Exclusion criteria
Exclusion criteria: 1. Individuals with a cardiac pacemaker, cochlear implants, other metal foreign objects, or any electronic equipment implanted in their body, and those with contraindications for MRI scans, such as claustrophobia, or contraindications for rTMS treatment; 2. Meeting diagnostic criteria for other psychiatric disorders such as schizophrenia, schizoaffective disorder, bipolar disorder, obsessive-compulsive disorder, secondary depression, etc. 3. History of epilepsy (at least 2 unprovoked seizures occurring more than 24 hours apart, diagnosed with an epilepsy syndrome, or had a seizure in the past 12 months); 4. Received magnetic seizure therapy (MST), electroconvulsive therapy (ECT), rTMS, or light therapy in the past 3 months; 5. Concurrent organic brain diseases (such as ischemic stroke, cerebral hemorrhage, brain tumor, etc.) and a history of severe traumatic brain injury; 6. Concurrent severe heart, liver, kidney diseases, diabetes, or other severe physical diseases; 7. Pregnant or breastfeeding women, and women of childbearing age who plan or may become pregnant during the trial; 8. History of drug or alcohol abuse in the past year; 9. First-degree relatives with bipolar disorder; 10. Significant suicide risk (MADRS item 10 score >= 5); 11. Difficulty in verbal communication to the extent that normal communication, understanding, or following instructions, and cooperation with treatment and assessment are impossible; 12. Currently participating in other drug or physical therapy clinical trials (such as deep brain stimulation (DBS), ECT therapy, rTMS); 13. Other situations deemed unsuitable by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale 17-item (HAMD17);Functional Magnetic Resonance Imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Treatment Emergent Symptom Scale;Global Assessment of Function Scale Score; | — |
Countries
China
Contacts
Public ContactRanran Li
Shandong mental health center
Outcome results
None listed