None
Conditions
Interventions
Tubeless Anesthesia Group:None
Double-lumen bronchial tube anesthesia group:None
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years; 2. American Society of Anesthesiologists (ASA) Physical Status I-III, New York Heart Association (NYHA) Functional Class I-II; 3. Body Mass Index (BMI) 50%, Ejection Fraction (EF) > 50%]; 6. No contraindications to paravertebral nerve block and intercostal nerve block; 7. Ability to sign informed consent and possess communication, reading, and writing skills; 8. Postoperative hospital stay of at least one day; 9. No preoperative sleep disorders, no cognitive dysfunction (Pittsburgh Sleep Quality Index (PSQI) score 27).
Exclusion criteria
Exclusion criteria: 1. Diagnosed with psychiatric disorders or a preoperative MMSE score < 27; 2. History of opioid abuse; 3. Patients admitted to the Intensive Care Unit (ICU) postoperatively; 4. Presence of severe cardiovascular, cerebrovascular, or respiratory diseases; 5. Critical rescue during or after surgery; 6. Concurrent coagulation disorders, severe hypoxemia or hypercapnia, or hepatic/renal insufficiency; 7. Difficult airway management; 8. Change of anesthetic agents or surgical plan; 9. History of severe lacunar cerebral infarction, ischemic stroke, or other neurological disorders; 10. Intraoperative change of anesthetic agents or surgical plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At time points T1, T2, and T3, 5 ml of peripheral venous blood was collected to test the biological indicators of postoperative cognitive function.;At the TI-T2 time point, 5 ml of peripheral venous blood was collected for the detection of HPA axis-related indicators.;Record the occurrence of adverse events during the perioperative period;Record the laboratory test indicators at time points T1 and T3;Record the vital signs at the T2 time point;Record the pulmonary function, chest X-ray or chest CT at time points T1 and T3;Record the intraoperative conditions;Record the time of chest tube removal after surgery, the usage of postoperative analgesic drugs, the postoperative hospital stay, and the total hospitalization cost.; | — |
Countries
China
Contacts
Public ContactLan Lan
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed