Depression
Conditions
Interventions
Accelerated Bilateral TBS Group:Using Yiruide magnetic stimulator with figure-8 coil, Beam F3 targeting method. Three times daily for 10 consecutive days (total 30 sessions). Parameters: left DLPFC re
right DLPFC received cTBS (1200 pulses, ~80 seconds), 30-minute interval between treatments. Intensity at 120% RMT (or 80–120% AMT).
Sham Control Group:Sham stimulation (reduced intensity threshold, coil positioned at 90 degrees, or emitting similar sounds and vibrations without effective stimulation), three times daily for 10 cons
Sponsors
Zigong Mental Health Center
Eligibility
Sex/Gender
All
Age
13 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for Major Depressive Disorder (MDD) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 2. Aged between 13 and 55 years, right-handed; 3. Total score of the Ruminative Responses Scale (RRS) > 50, indicating significant rumination symptoms; 4. Volunteer to participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. A history of epilepsy or severe organic brain disease; 2. Presence of metallic implants in the body (e.g., cardiac pacemaker, deep brain stimulation electrodes); 3. Comorbid bipolar disorder, schizophrenia, or other psychotic disorders; 4. Presence of severe and unstable physical or neurological diseases; 5. Received electroconvulsive therapy (ECT) within the past 3 months; 6. Conditions unsuitable for MRI scanning, such as ferromagnetic metal implants or claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of the Ruminative Response Scale (RRS) score. ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction rate of the 17-item Hamilton Depression Rating Scale (HAMD-17) score.;Reduction rate of the Montgomery-?sberg Depression Rating Scale (MADRS) score.;Reduction rate of the Generalized Anxiety Disorder 7-item scale (GAD-7) score.;Reduction rate of the Columbia-Suicide Severity Rating Scale (C-SSRS) score.;fMRI brain imaging metrics.; | — |
Countries
China
Contacts
Public ContactTan Youguo
Zigong Mental Health Center
Outcome results
None listed