Post-Stroke Cognitive Impairment
Conditions
Interventions
ITF group:ITF HD-tACS: The stimulation intensity is 1mA, with a stimulation duration of 20 minutes, applied continuously for 10 days, once per day.
5Hz group:5Hz HD-tACS: The stimulation intensity is 1mA, with a stimulation duration of 20 minutes, applied continuously for 10 days, once per day.
Sham group:sham stimulation: The stimulation intensity is 1mA, with a stimulation duration of 20 minutes, applied continuously for 10 days, once per day.
Sponsors
Center of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Montreal Cognitive Assessment Scale (MoCA) score <=25; 2.First-ever stroke, Cognitive impairment should occur within 12 months of the vascular event and last for at least 1 months; 3.Age 18 to 80 years, Right-handed; 4.Normal cognitive function before stroke; 5.Stable vital signs; 6.No severe vision, hearing impairment and capable of completing cognitive tests; 7.Obtain the consent of the patient and his family, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Complete damage to the left prefrontal cortex confirmed by CT/MRI; 2.Bilateral brain lesions; 3.Defect of the skull; 4.Use of antidepressants or psychostimulants; 5.Metal or cardiac pacemaker implants near the treatment site; 6.Brain disorders such as brain tumors, brain trauma, and seizures; 7.Unstable vital signs or failure of vital organs; 8.Any neuropsychiatric comorbidity or affective disorder that could affect the test results; 9.Patients are unable to cooperate with the cognitive assessment and intervention described below.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal cognitive assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test;Digit Span Test;Symbol Digit Modalities Test;Power spectral density;Adverse events;Phase locking value; | — |
Countries
China
Contacts
Public ContactWang Kangling
Rehabilitation Medicine Center of Zhujiang Hospital, Southern Medical University
Outcome results
None listed