delta biological age
Conditions
Interventions
Control Group:Anti-aging Protocol Based on the Four Rational Lifestyle Principles
Experimental Group:Intervention based on the Four-Rationality Anti-Aging Program and oral administration of the investigational product
Sponsors
The Central Hospital of Wuhan
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Male or female permanent residents of Wuhan City, aged 40 to 60 years. 2. Willing to participate in this study, capable of understanding the study procedures, and able to sign a written informed consent form approved by the Ethics Committee. 3. Committed to adhering to the study protocol, including taking the product on schedule, attending all scheduled follow-up visits, and agreeing not to use other anti-aging products during the randomized controlled trial. 4. No habit of consuming energy drinks (e.g., Red Bull) and no history of cosmetic dermatological procedures (e.g., hyaluronic acid injections). 5. Agrees to maintain relatively stable dietary and exercise habits throughout the study period, except as required by the intervention, and to report any changes truthfully.
Exclusion criteria
Exclusion criteria: 1.Subjects meeting any of the following criteria will be excluded from this trial: 1. Subjects who have participated in or are currently participating in other clinical trials within three months of their first dose of the study product. 2. Subjects with known allergies to any ingredients in the investigational product or the control product. 3. Subjects diagnosed with major chronic diseases. 4. Subjects suffering from immune system or gastrointestinal disorders. 5. Subjects with a history of cancer. 6. Subjects who are long-term users of anti-inflammatory or antioxidant supplements. 7. Women who are planning to become pregnant, are currently pregnant, or are breastfeeding. 8. Subjects with a history of long-term heavy alcohol consumption or smoking. 9. Subjects who are long-term users of supplements known to potentially affect epigenetic age or aging pathways, such as NAD+ precursors, rapamycin, metformin, resveratrol, Ganoderma lucidum (Reishi), etc. 10. Subjects with communication or cognitive impairments. 11. Subjects with psychiatric disorders. 12. Any other subjects deemed unsuitable for participation in this study by the investigator. 13. Subjects who have not signed the informed consent form. 14. Subjects unable to comply with follow-up requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DunedinPACE;GrimAge;kidney function;DNAm PhenoAge;liver function; | — |
Secondary
| Measure | Time frame |
|---|---|
| longevity factor;systemic inflammatory markers;routine urine and stool tests;leukocyte telomere length; | — |
Countries
China
Contacts
Public ContactChen Wenli
The Central Hospital of Wuhan
Outcome results
None listed