Functional constipation
Conditions
Interventions
Control Group:Sham rTMS (0 Hz/s, 0 MT, 20 min/d, once daily for 4 weeks) + Lactulose (initial 30 ml/d, maintenance 15 ml/d, for 4 weeks)
Trial Group 1:rTMS (1 Hz/s, 80% MT, 20 min/d, once daily for 2 weeks) + Sham rTMS (0 Hz/s, 0 MT, 20 min/d, once daily for 2 weeks) + Lactulose (initial 30 ml/d, maintenance 15 ml/d, for 4 weeks)
Trial Group 2:rTMS (1 Hz/s, 80% MT, 20 min/d, once daily for 4 weeks) + Lactulose (initial 30 ml/d, maintenance 15 ml/d, for 4 weeks)
Sponsors
Suzhou Xiangcheng People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Meets the diagnostic criteria of FC as per Roman IV classification; 2.The symptoms of constipation have persisted for = 6 months; 3.The ages range from 18 to 75 years old; 4.Voluntarily participate in this research and sign the relevant informed consent form;
Exclusion criteria
Exclusion criteria: 1.Secondary constipation caused by other organic diseases and medication factors; 2.Those with severe diseases of the heart and blood vessels, liver, kidneys, blood system, nervous and mental systems, as well as cognitive impairments are included; 3.Has a history of gastrointestinal and pelvic surgeries; 4.Having metallic or electronic devices implanted in the body; 5.Taking drugs that affect the intestinal flora and gastrointestinal motility within the past two weeks; 6.There are cases of intestinal obstruction, perforation, bleeding, tumors, acute pancreatitis, appendicitis, and unexplained abdominal pain; 7.Diabetes and lactose allergy or intolerance; 8.Pregnant women and lactating mothers;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| complete spontaneous bowel movement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient Assessment of Constipation Quality of Life;Patient Assessment of Constipation Symptoms;Bristol Stool Form Scale;Anorectal pressure measurement;Self-rating depression scale;Self-Rating Anxiety Scale; | — |
Countries
China
Contacts
Public ContactXu Xuefei
Suzhou Xiangcheng People’s Hospital
Outcome results
None listed