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Clinical outcomes of connective tissue grafting versus guided bone regeneration in anterior implant sites with unfavorable buccal bone defects: a retrospective cohort study

Clinical outcomes of connective tissue grafting versus guided bone regeneration in anterior implant sites with unfavorable buccal bone defects: a retrospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600121219
Enrollment
Unknown
Registered
2026-03-26
Start date
2026-03-26
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-implant tissue defect

Interventions

Guided bone regeneration (GBR) group:None
Connective tissue graft (CTG) group:None

Sponsors

West China Hospital of Stomatology, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years. 2. Single tooth loss in the anterior region treated with implant-supported restoration. 3. Presence of a buccal bone defect after implant placement, with the defect extent < 50% of the implant length (classified as a 1/4-type defect according to the Terheyden classification; Cordaro et al., 2019). 4. Patients who received guided bone regeneration (GBR) or connective tissue grafting (CTG) during implant placement or during the restorative phase. 5. Distance between the buccal surface of the implant and the theoretical buccal bone arch contour <= 2 mm. 6. Generally healthy or medically stable patients who can tolerate routine implant therapy.

Exclusion criteria

Exclusion criteria: 1. Presence of severe systemic diseases (e.g., uncontrolled diabetes mellitus or immune disorders). 2. Long-term use of medications that may affect bone metabolism or wound healing. 3. Heavy smoking or chronic alcohol abuse. 4. Poor oral hygiene or uncontrolled periodontal disease. 5. Pregnancy or history of radiotherapy in the head and neck region.

Design outcomes

Primary

MeasureTime frame
Linear and volumetric change of buccal soft tissue profile;

Secondary

MeasureTime frame
Midfacial recession;Pink Esthetic Score, PES;Mucosal Scarring Index, MSI;Implant survival;Marginal bone loss, MBL;Modified sulcus bleeding index, mSBI;Modified plaque index, mPI;Probing depth, PD;

Countries

Chine

Contacts

Public ContactXiong Yi

West China Hospital of Stomatology, Sichuan University

xiongraise@163.com+86 181 4018 9201

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 4, 2026