Chronic daily headache
Conditions
Interventions
Experimental group:Preventive drug Tizanidine
Control group:Preventive drug Topiramate
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-65 years old 2.Meets the diagnostic criteria for chronic headache disorders in ICHD-3 3.Informed consent, signing a written informed consent form 4.Able to complete relevant data recording and scale evaluation according to regulations
Exclusion criteria
Exclusion criteria: 1.use of two or more classes of preventive medications (i.e. antidepressants, antiepileptics, anxiolytics, muscle relaxants, ß-blockers) within the two months prior to enrollment 2.presence of severe anxiety, depression, or sleep disorders; 3. a history of hepatic or renal insufficiency; psychiatric illness; serious neurological or systemic diseases; malignant tumors; or alcohol abuse; 4. current participation in other clinical trials were also excluded 5. being a study investigators or having immediate family member (i.e. parents, spouses, siblings, or children) involved in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Headache frequency;Average Headache Degree (Visual Analog Scale VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of headache; | — |
Countries
China
Contacts
Public ContactTao Tao
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed