Community Acquired Pneumonia
Conditions
Interventions
PK/PD study section-Cefotaxime observation group:None
Real-world study section-Cefotaxime observation group:None
Sponsors
Qingdao Women and Children's Hospital?
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for the PK/PD Study Section (1) Children aged 0–18 years (2) Diagnosed with community-acquired pneumonia according to the Guidelines for the Management of Community-Acquired Pneumonia in Children (2024 Revision) (3) Treated with ceftriaxone for more than 2 days (4) Informed consent voluntarily signed by the children's guardians 2. Inclusion Criteria for the Real-World Study (1) Meet the diagnostic criteria of the Guidelines for the Management of Community-Acquired Pneumonia in Children (2024 Revision) (2) Age < 18 years (3) Require treatment with ceftriaxone (4) Informed consent voluntarily signed by the children's guardians
Exclusion criteria
Exclusion criteria: 1. Exclusion Criteria for the PK/PD Study Section (1) Patients allergic to ceftriaxone (2) Concurrent severe diseases, such as cardiovascular diseases, kidney diseases, liver diseases, hematological disorders, etc. (3) Patients currently participating in other clinical drug trials (4) Other conditions deemed unsuitable for inclusion in this study by the researchers, such as lack of accurate medication administration or blood sampling information 2. Exclusion Criteria for the Real-World Study (1) Allergy to ceftriaxone (2) Concurrent use of other antibacterial drugs (3) Patients with concurrent immunological diseases (4) Poor compliance or inability to follow the prescribed medication regimen for any reason (5) Patients with concurrent congenital diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood drug concentration;Drug concentration in ELF;The efficacy rate of the optimized regimen of ceftriaxone;The time for improvement of clinical symptoms;Inflammation-related indicators: Whole blood white blood cell count (WBC), neutrophil percentage, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), lactate dehydrogenase (LDH), D-dimer (DD); | — |
Countries
China
Contacts
Public ContactLiu Chang
Qingdao Women and Children's Hospital?
Outcome results
None listed