Alzheimer's Disease (AD)
Conditions
Interventions
Sham rTMS group:Sham rTMS
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of probable Alzheimer's disease dementia according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria: reports of gradual and progressive decline in memory function, disease course >= 6 months, MRI showing medial temporal lobe atrophy; 2. Age 50-75 years; 3. Montreal Cognitive Assessment (MoCA) score: 10-25; 4. Clinical Dementia Rating (CDR) score: 1-2; 5. Good visual, auditory, and speech abilities, and able to cooperate to complete neuropsychological assessments and auxiliary examinations required for the study; 6. At least one reliable caregiver; 7. Patient and/or family voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Exclude other diseases that cause cognitive impairment, such as vascular dementia, frontotemporal dementia, etc.; 2. Patients with other central nervous system diseases, such as Parkinson's disease, epilepsy, etc.; 3. Exclude a history of severe mental illness; 4. History of substance abuse or drug dependence; 5. Combined severe dysfunction of the heart, liver, or kidneys; 6. Metal implants at the stimulation site; 7. Absolute contraindications for functional magnetic resonance imaging; 8. Continuous use of antibiotics or probiotics within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Score;Clinical Dementia Rating Score;Alzheimer Disease Assessment Scale-Cognitive Score; | — |
Countries
China
Contacts
Public ContactJi Yingying
Wuxi Mental Health Center
Outcome results
None listed