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Research on perioperative risk prediction and personalized management of atrial fibrillation driven by multidimensional biomarkers

Research on perioperative risk prediction and personalized management of atrial fibrillation driven by multidimensional biomarkers

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600121153
Enrollment
Unknown
Registered
2026-03-26
Start date
2026-03-31
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation

Interventions

Modeling Group:None

Sponsors

The First Affiliated Hospital of Guangzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age range: 18-75 years old; 2. Diagnosed with atrial fibrillation through 12 lead electrocardiogram or dynamic electrocardiogram (according to the 2020 ESC guidelines for atrial fibrillation), and with a disease course of >= 6 months; 3. Proposed catheter ablation therapy; 4. Sign a written informed consent form

Exclusion criteria

Exclusion criteria: 1. Transesophageal ultrasound or cardiac CT confirms the presence of left atrial thrombus; 2. Severe heart valve disease; 3. Uncontrolled hyperthyroidism; 4. Acute coronary syndrome has occurred within the past 3 months; 5. Patients with severe liver and kidney dysfunction; 6. History of recurrent arrhythmia intervention; 7. And other situations where the researchers determine that the subjects are not suitable to participate in this study.

Design outcomes

Primary

MeasureTime frame
Incidence rate of MACE events within 12 months after surgery (including cardiac death, stroke, acute coronary syndrome, heart failure hospitalization);Recurrence rate of atrial fibrillation;Model evaluation: (1) Discriminative power: ROC curve, C-index; (2) Calibration degree: Hosmer-Lemeshow test, calibration curve; (3) Clinical value: Decision Curve Analysis (DCA).;

Secondary

MeasureTime frame
Postoperative rhythm stability;Improvement in quality of life score;

Countries

China

Contacts

Public ContactChen Ailan

The First Affiliated Hospital of Guangzhou Medical University

chenailan5496@sina.com+86 133 9247 9416

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 4, 2026