Obsessive-compulsive disorder
Conditions
Interventions
Experimental group:Transcranial magnetic stimulation parameters
Control group2:Sham stimulation, no transcranial magnetic stimulation
the healthy control group:Only complete the baseline assessment, no intervention will be carried out
Control group1:Standardised TMS stimulation parameters
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria for OCD patients:(1) Age 18-55 years: This age range is a high incidence period for obsessive-compulsive disorder, and the physiological state is relatively stable, allowing better tolerance of TMS treatment; 2.Inclusion criteria for OCD patients:(2) Meet the DSM-5 diagnostic criteria for obsessive-compulsive disorder and have a Y-BOCS score >=20: ensures uniform severity of the disease among study subjects, all being moderate to severe cases, which is conducive to evaluating therapeutic effects; 3.Inclusion criteria for OCD patients:(3) Stable on medication for more than 4 weeks or not taking medication: exclude drug interference factors to ensure that the efficacy is attributed to TMS intervention; 4.Inclusion criteria for OCD patients:(4) No history of neurostimulation treatment in the past 3 months: to avoid interference of previous treatments with the results of this study; 5.Inclusion criteria for OCD patients:(5) Ability to provide informed consent: to protect the rights of participants and meet ethical requirements; 6.Inclusion criteria for OCD patients:(6) Voluntarily signing the informed consent form: reflects the principle of autonomy and ensures research compliance; 7.Inclusion criteria for the healthy control group:(7) Demographic matching (age, gender): ensure comparability with the baseline of the patient group; 8.Inclusion criteria for the healthy control group:(8) No mental illness detected by MINI screening: confirmed to be in a mentally healthy state, providing normal control data; 9.Inclusion criteria for the healthy control group:(9) Capable of giving informed consent and voluntarily participating: ethical requirements for the same patient group;
Exclusion criteria
Exclusion criteria: 1.Common exclusion criteria:(1) Absolute contraindications for TMS (epilepsy, intracranial metal implants, etc.): ensure treatment safety and avoid serious adverse events; 2.Common exclusion criteria:(2) Comorbidity of severe mental illnesses: exclude confounding factors of diseases to ensure the homogeneity of research subjects; 3.Common exclusion criteria:(3) High-risk suicidal behaviour (BDI II>39 points): Protecting vulnerable populations based on safety and ethical considerations; 4.Common exclusion criteria:(4) Pregnant/lactating women: avoid potential risks to the fetus/infant; 5.Common exclusion criteria:(5) Severe physical illness: ensure the ability to tolerate the study process and reduce the risk of dropout; 6.Specific exclusion criteria:(6) Additional exclusions for the healthy control group: taking psychiatric medication in the past three months, to ensure a clean baseline state;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Y-BOCS Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| WCST Executive Function;SF-36 Quality of Life; | — |
Countries
China
Contacts
Public ContactShengnan Zhao
Ningbo University Affiliated Kangning Hospital
Outcome results
None listed