Acute Type A Aortic Dissection
Conditions
Interventions
Ciprofol group:After the patient emerges from general anesthesia and is assessed to have no disturbance of consciousness, with a Richmond Agitation-Sedation Scale (RASS) score greater than 0, analgesi
Sponsors
Henan Provincial Chest Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing invasive mechanical ventilation following aortic dissection surgery with cardiopulmonary bypass. 2.Glasgow Coma Scale (GCS) score > 8. 3.No postoperative disturbance of consciousness, with a target Richmond Agitation-Sedation Scale (RASS) score of -2 to 0, and an expected sedation duration of 6 to 48 hours after randomization. 4.Age between 18 and 75 years (inclusive). 5.Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant or breastfeeding women. 2.Severe pre-existing parenchymal liver disease with clinically significant portal hypertension, Child-Pugh Class C cirrhosis, or acute liver failure. 3.Dissection involving the head and neck vessels or pre-existing encephalopathy before surgery. 4.Patients with bronchial asthma, chronic obstructive pulmonary disease (COPD), or myasthenia gravis. 5.Patients with a history of alcohol or drug abuse. 6.Inability to obtain informed consent or authorization. 7.Patients not requiring sedation or analgesia therapy. 8.Mean arterial pressure (MAP) < 55 mmHg. 9.Receipt of two or more types of sedative or analgesic medications within 24 hours. 10.Patients with a known allergy to propofol, ciprofol, or remifentanil hydrochloride.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of mean arterial pressure change from baseline (MAP-AUC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Total vasopressor dose (norepinephrine equivalent);Incidence of acute kidney injury (AKI);Serum inflammatory markers (interleukin-6, IL-6) levels;Duration of mechanical ventilation;Incidence of delirium; | — |
Countries
China
Contacts
Public ContactHe Faming
Henan Provincial Chest Hospital of Zhengzhou University
Outcome results
None listed