Obsessive-compulsive disorder
Conditions
Interventions
Individualized Treatment Group:rs-TMS Individualized Treatment
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for obsessive-compulsive disorder (OCD) in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). 2.Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score >= 16. 3.Male or female, any ethnicity, aged 16–60 years, and right-handed. 4.Educational attainment at primary school or above, able to understand task requirements and complete questionnaires. 5.Provide written informed consent signed by the participant or their legal guardian. 6.No prior pharmacotherapy for OCD before enrollment.
Exclusion criteria
Exclusion criteria: 1.Subjects with any other psychiatric disorder. 2.Subjects with a history of epilepsy, substance abuse, severe head injury, or any neurosurgical procedure. 3.Individuals with contraindications to MRI scanning, including claustrophobia, metallic implants, pacemakers, etc. 4.Pregnant or lactating women. 5.Subjects who have received electroconvulsive therapy (ECT) within the past 6 months. 6.Individuals with contraindications to MRI or abnormal brain structure detected by MRI. 7.Individuals unwilling or unable to complete the entire study procedure or comply with the study treatment plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate defined by the reduction in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score at Day 14 (end of treatment); | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Global Impression - Severity Scale Score; | — |
Countries
China
Contacts
Public ContactChunxiao Dai
Hangzhou First People's Hospital
Outcome results
None listed