Alzheimers disease
Conditions
Interventions
Observation group:None
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Age range: adults aged 18–40 years; 2.Self-reported health status: No known history of chronic diseases such as cardiovascular, cerebrovascular, metabolic (e.g., diabetes), hepatic, renal, endocrine, or hematologic disorders; no history of fever, infection, trauma, or surgery within the 4 weeks prior to enrollment. 3.Participants should have maintained a regular sleep-wake cycle recently, with no disruptions to circadian rhythms such as frequent night shifts or transmeridian travel. 4.No special dietary regimens (including but not limited to extreme dieting) and no use of any medications (including contraceptives, supplements, etc.) that may affect test results prior to enrollment and throughout the study period. 5.Capable of understanding and signing the informed consent form and committed to strictly adhering to the study protocol (e.g., arriving on time, maintaining fasting status for blood collection, etc.).
Exclusion criteria
Exclusion criteria: 1.Concurrent significant organ failure or dysfunction. 2.History of hemorrhagic or ischemic stroke (including cerebral infarction with an infarct diameter =1 cm). 3.Concurrent cognitive impairment due to any cause, including but not limited to intracranial tumors, metabolic disorders, traumatic brain injury, epilepsy, frontotemporal dementia, or Lewy body dementia; or any other concurrent neuropsychiatric disorders. 4.Rapid cognitive deterioration or stepwise progression, or post-stroke cognitive impairment occurring within 3 months of stroke. 5.Has taken psychoactive medications within the 3 months prior to enrollment. 6.Patients with severe language, hearing, or visual impairment that prevents cooperation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of biomarkers Aß40, Aß42, p-tau181, and p-tau217; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of GFAP and NfL;Differences in blood pressure, heart rate, and body temperature at different time points during blood collection; | — |
Countries
China
Contacts
Public ContactBeiyu Zhao
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed