HIV infection
Conditions
Interventions
Regimen 1: Switch to INSTIs regimen:None
Regimen 2: Switch to protease inhibitor regimen:None
Regimen 3: Maintain original regimen:None
Regimen 4: Switch to INSTIs regimen:None
Regimen 5: Maintain original regimen:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old 2. Patients who have been treated for HIV-1 for 2 years or more and are on ART. 3. Non-nucleoside regimens such as 2 NRTIs + EFV/NVP, or protease inhibitors like 2 NRTIs + LPV/r 4. The latest HIV viral load is >= 50 copies/ml 5. Patients who have switched treatment regimens due to intolerance/drug resistance recently 6. Patients who are willing and able to sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Having organic mental disorders 2. Pregnant and lactating women 3. Due to treatment of comorbidities, there are DDIs between the current treatment plan and the ART regimen (such as patients with tuberculosis, etc.) 4. Those with poor compliance 5. Patients with malignant tumors or severe cardiovascular, cerebrovascular, coagulation, or autoimmune diseases 6. Any other conditions deemed unsuitable for the trial by the researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in HIV reservoir size;CD4+ T cell count;Plasma HIV RNA level;Patient survival outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in HIV reservoir size at week 0, 24, and 96;CD4 count and plasma HIV RNA level at week 0, 24, and 96;Changes in plasma cytokine or chemokine expression levels (e.g., IFN-?, IL-6, MIG);Incidence rate of adverse events;Incidence of HIV-related opportunistic infections;Number of hospitalizations;HIV virologic failure rate;Adherence; | — |
Countries
China
Contacts
Public ContactTang Hong
West China Hospital of Sichuan University
Outcome results
None listed