Reproductive tract malformation
Conditions
Interventions
Observation group:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
14 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Time frame: Patients treated at Peking Union Medical College Hospital between January 1, 1994 and December 31, 2025 were enrolled. This endpoint was set to ensure that all included cases had a potential follow-up window of at least 1 year at the time of data extraction in 2026. 2.Diagnostic criteria: Patients were required to meet both of the following: (1) Genital tract malformations (including but not limited to septate uterus, uterus didelphys, bicornuate uterus, unicornuate uterus, rudimentary horn uterus, oblique vaginal septum syndrome, etc.) diagnosed by ultrasonography, magnetic resonance imaging (MRI), hysterosalpingography (HSG), and/or laparoscopy; (2) Ectopic pregnancy (including tubal pregnancy, ovarian pregnancy, abdominal pregnancy, cervical pregnancy, pregnancy in rudimentary horn, cornual pregnancy, etc.) confirmed by clinical evaluation, serum human chorionic gonadotropin (hCG) monitoring, ultrasonography, and/or postoperative pathological examination. 3.Age: Age >= 14 years at presentation. 4.Follow-up requirement: After treatment for the index ectopic pregnancy, patients had at least one subsequent visit (either outpatient or inpatient) at Peking Union Medical College Hospital related to the index disease or reproductive health to meet the minimum follow-up criteria.
Exclusion criteria
Exclusion criteria: 1.Uncertain diagnosis: Insufficient or questionable evidence for the diagnosis of genital tract malformation or ectopic pregnancy. 2.Severe data missing: Lack of key medical records, treatment data or outcome information that renders valid analysis impossible. 3.Complicated with other severe reproductive diseases: Concurrent malignant tumors of the reproductive system (e.g., cervical cancer, endometrial cancer, ovarian cancer, etc.). 4.Iatrogenic or post-traumatic malformations: Genital tract malformations definitely caused by acquired surgery, radiotherapy or trauma. 5.Concurrent intrauterine and extrauterine pregnancy: Such cases may be analyzed separately as a subgroup (this criterion can be adjusted according to the study design; cases may be either excluded or included as a subgroup).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment success rate (blood hCG successfully drops to normal without additional intervention);Treatment-related complications (such as failure of conservative drug therapy, surgical collateral injury, bleeding, infection, persistent ectopic pregnancy, etc.) and their management;Time for blood hCG to return to normal; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subsequent natural pregnancy situation;Follow-up visits due to infertility and the situation of receiving assisted reproductive treatment;Outcome of symptoms related to reproductive tract malformations;Long-term complications; | — |
Countries
China
Contacts
Public ContactLin Qiu
Peking Union Medical College Hospital
Outcome results
None listed