Etomidate-induced general anesthesia with laryngeal mask airway
Conditions
Interventions
Experimental group:According to the modified Dixon up-and-down method, the dose of tianeptine for laryngeal mask airway insertion during etomidate induction in elderly patients was determined. The fir
Sponsors
The second hospital & clinical medical school.lanzhou university
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Male and female patients, ASA physical status ?-?, aged =65 years, with a body mass index of 18-30 kg/m², scheduled for etomidate-induced general anesthesia with a laryngeal mask airway.
Exclusion criteria
Exclusion criteria: 1.Refusal to participate in this study. 2.Inability to cooperate or communicate in Chinese. 3.Participation in other clinical studies. 4.Currently taking any analgesic medication. 5.History of opioid abuse. 6.Comorbidities involving the heart, brain, liver, kidneys, or other major organs. 7.Contraindications to laryngeal mask airway insertion, such as a full stomach, facial deformity, or limited mouth opening. 8.Hemodynamic instability, such as hypertension or tachycardia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Laryngeal mask airway insertion response score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The maximum values of MAP and HR, and the minimum value of SpO? during the induction period after tegileridine injection.;The incidence of hypertension, hypotension, bradycardia, tachycardia, and hypoxemia (SpO? < 90%) during the induction period after tegileridine injection.;The use of ephedrine and atropine during the induction period.;Intra-induction etomidate supplementation;The Ramsay Sedation Score of patients at 3 minutes after tegileridine injection.;Number of laryngeal mask airway insertion attempts;Conversion to general anesthesia with endotracheal intubation;The occurrence of etomidate injection pain.;Latency to loss of consciousness, defined as the time interval from tianeptine injection to loss of consciousness.;BIS latency, defined as the time interval from patient awakening to the decrease of BIS to 60 after tegileridine injection.;Incidence of adverse reactions (including coughing during induction, muscle rigidity, muscle tremors, limb movement, hiccups, allergic reactions, dizziness, etc.).;Patient baseline characteristics; | — |
Countries
China
Contacts
Public ContactZhang Jingyu
The second hospital & clinical medical school.lanzhou university
Outcome results
None listed