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Continuous theta-burst stimulation of the orofacial motor cortex modulates corticobulbar excitability and craving in individuals who smoke: A randomized, crossover, sham-controlled trial

Continuous theta-burst stimulation of the orofacial motor cortex modulates corticobulbar excitability and craving in individuals who smoke: A randomized, crossover, sham-controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600121024
Enrollment
Unknown
Registered
2026-03-24
Start date
2026-03-31
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nicotine dependence

Interventions

cTBS group:targeting the orofacial motor cortex using standard cTBS protocol
Sham group:Sham stimulation using coil tilt method to minimize participants’ awareness of stimulation intensity and location

Sponsors

Shanghai University of Sport
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Thirty smokers were needed. All participants were right-handed and had normal or corrected-to-normal vision.

Exclusion criteria

Exclusion criteria: 1. A history of organic brain disease, traumatic brain injury, head surgery, metallic implants in the skull, or increased intracranial pressure; 2. The presence of intracardiac metal stents or leads, or a cardiac pacemaker; 3. Use of a hearing aid; 4. A family history of epilepsy or a personal history of epileptic seizures; 5. A history of electroconvulsive therapy.

Design outcomes

Primary

MeasureTime frame
Changes in subjective smoking craving ratings (VAS, 0-10);Changes in QSU-Brief questionnaire scores;Changes in cue-induced orofacial motor cortex MEP amplitude;

Countries

China

Contacts

Public ContactJian Zhang

Shanghai University of Sport

zhangjian@sus.edu.cn+86 135 2474 9688

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 4, 2026