Autoimmune Encephalitis
Conditions
Interventions
Other autoimmune encephalitis:NA
Anti-NMDAR encephalitis group:NA
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
14 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 14–75 years; 2. Meet the 2016 international diagnostic criteria for autoimmune encephalitis (AE), with definite AE-associated antibodies detected in serum/cerebrospinal fluid (anti-NMDAR, anti-GABABR, anti-LGI1, anti-CASPR2, or other well-recognized AE antibodies); 3. Time from diagnosis <= 3 months (to ensure capture of early disease burden characteristics); 4. Voluntary signed informed consent by the patient or their legal guardian (for minors/individuals without full civil capacity); 5. Able to cooperate and complete the 12-month follow-up (including questionnaire completion, clinical re-examination, telephone follow-up, etc.); 6. Able to provide complete medical records (fee lists, treatment regimens, examination reports) for data verification.
Exclusion criteria
Exclusion criteria: 1. A definite diagnosis of other central nervous system diseases, such as infectious encephalitis (HSV, Epstein–Barr virus, etc.), metabolic encephalopathy, cerebrovascular disease, brain tumor, etc. 2. Participation in >= 2 other clinical studies simultaneously, or a washout period of less than 1 month since the last clinical trial medication. 3. Presence of severe underlying diseases including hepatic and renal insufficiency, coagulation dysfunction, etc., that prevent completion of long-term follow-up. 4. Caregivers refuse to provide information related to economic status and quality of life. 5. Incomplete medical records, making it impossible to extract medical cost or survival data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cumulative economic burden at 12 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological function scores;Health related quality of life; | — |
Countries
China
Contacts
Public ContactXiangjun Chen
Huashan Hospital, Fudan University
Outcome results
None listed