Epilepsy
Conditions
Interventions
Epilepsy with comorbid mood disorders group (COM group):None
Simple epilepsy group (EPI group):None
Healthy control group (CON group):None
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Epilepsy with comorbid mood disorders group (COM group); 1. Age: 18–65 years; 2. Gender: Not restricted ;3. Compliance with the Diagnostic Criteria for Epilepsy (DCE) of the International League Against Epilepsy (ILAE); 4. According to the standardized scale, there is emotional disorder, which meets any of the following conditions: bdi>=14 (depression); Hama>=7 points (anxiety);5. Complete and traceable key clinical data and biological samples, including but not limited to demographic information, seizure and medication history, complete mood scale scores, complete blood count (CBC) and biochemical test results on the first day of hospitalization, available electroencephalogram (EEG) and neuroimaging (MRI/PET) data, as well as properly preserved peripheral blood, saliva, urine samples, and brain tissue. Simple epilepsy group (EPI group); 1. Age: 18–65 years; 2. Gender: Not restricted; 3. Meeting the diagnostic criteria for epilepsy as defined by the International League Against Epilepsy (ILAE); 4. No clinical diagnostic thresholds for depression or anxiety as assessed by HAMA, BDI, or HADS; 5. Matching with the COM group in terms of age, gender, disease duration, and presence of refractory epilepsy; 6. Complete and traceable key clinical data and biological samples, including but not limited to demographic information, seizure and medication history, complete mood scale scores, complete blood count and biochemical test results on the first day of hospitalization, available electroencephalogram (EEG) and neuroimaging (MRI/PET) data, as well as properly preserved peripheral blood, saliva, urine samples, and brain tissue. Healthy control group (CON group); 1. Age 18–65 years; 2. No gender restriction; 3. No history of epilepsy, depression, anxiety, or other neuropsychiatric disorders; 4. HAMA, BDI, and HADS scores below abnormal thresholds; 5. Age and gender matched with the patient group; 6. Complete and traceable key clinical data and biological samples, including but not limited to demographic information, complete mood scale scores, and properly preserved peripheral blood, saliva, and urine samples.
Exclusion criteria
Exclusion criteria: Epilepsy with comorbid mood disorders group (COM group); 1. Admission with other severe central nervous system disorders (e.g., stroke, neurodegenerative diseases, etc.); 2. Previously diagnosed with schizophrenia, bipolar disorder, or other severe mental illnesses; 3. Admission with concurrent acute/chronic infections, systemic inflammatory diseases, or malignancies; 4. Pregnant or lactating women. Simple epilepsy group (EPI group); 1. Previous or current neurological or psychiatric disorders; 2. Concurrent acute/chronic infections, systemic inflammatory diseases, or immune system disorders at admission; 3. Severe somatic diseases or malignancies at admission; 4. Pregnant or lactating women. Healthy control group (CON group); 1. Previous or current neurological or psychiatric disorders; 2. Concurrent acute/chronic infections, systemic inflammatory diseases, or immune system disorders; 3. Concurrent severe somatic diseases or malignancies; 4. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of a-KG;Beck Depression Inventory Score and Hamilton Anxiety Rating Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Protein expression profile, metabolite profile; | — |
Countries
China
Contacts
Public ContactZhao Guoguang
Xuanwu Hospital Capital Medical University
Outcome results
None listed