None
Conditions
Interventions
Experimental group: Remifentanil group :Anesthesia induction protocol of remifentanil (0.95ug/kg) combined with remimazolam (0.3mg/kg)
Control group: Sufentanil group:Anesthesia induction protocol of sufentanil (0.3ug/kg) combined with remimazolam (0.3 mg/kg)
Sponsors
Linyi People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Voluntarily sign the informed consent form; 2) Age >=60. 3) ASA I to III. 4) BMI: 20-27.9kg/m^2. 5) It is planned to conduct puncture pressure measurement. 6) Patients undergoing general anesthesia with a single lumen tube.
Exclusion criteria
Exclusion criteria: 1) Difficult airway or failure of the first intubation; 2) Currently using benzodiazepines or having a history of allergy to benzodiazepines; 3) Currently using opioid drugs or other painkillers; 4) Poorly controlled hypertension (SBP > 180mmHg); 5) History of ischemic heart disease; 6) HR < 55bpm 7) History of stroke; 8) Severe liver, kidney and lung diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve (AUC) of mean arterial pressure (MAP) within the first 15 minutes after anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypotension within 15 minutes after induction of anesthesia;Temporary pacemaker activation requirements (heart rate < 50 beats/min);Lowest mean arterial pressure (MAP);Cumulative dose of vasopressor drugs;Dose of anesthetics;Bispectral index (BIS) values were measured within 15 minutes after induction;Duration of loss of consciousness (LOC);Percentage of duration of BIS values between 40 and 60 and indicators of postoperative recovery; | — |
Countries
China
Contacts
Public ContactZiyao Jiao
Linyi People's Hospital
Outcome results
None listed